Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumonia

INTRODUCTION: Nuclear factor (NF)-κB is central to the pathogenesis of inflammation in acute lung injury, but also to inflammation resolution and repair. We wished to determine whether overexpression of the NF-κB inhibitor IκBα could modulate the severity of acute and prolonged pneumonia-induced lun...

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Autors principals: Devaney, James, Curley, Gerard F, Hayes, Mairead, Masterson, Claire, Ansari, Bilal, O'Brien, Timothy, O'Toole, Daniel, Laffey, John G
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056114/
https://ncbi.nlm.nih.gov/pubmed/23622108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc12696
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