Hypercapnic acidosis attenuates pulmonary epithelial stretch-induced injury via inhibition of the canonical NF-κB pathway

BACKGROUND: Hypercapnia, with its associated acidosis (HCA), is a consequence of respiratory failure and is also seen in critically ill patients managed with conventional “protective” ventilation strategies. Nuclear factor kappa-B (NF-κB), a pivotal transcription factor, is activated in the setting...

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Publicado en:Intensive Care Med Exp
Autores principales: Horie, Shahd, Ansari, Bilal, Masterson, Claire, Devaney, James, Scully, Michael, O’Toole, Daniel, Laffey, John G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer International Publishing 2016
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801837/
https://ncbi.nlm.nih.gov/pubmed/27001525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-016-0081-6
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