Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis

INTRODUCTION: A major pathophysiologic mechanism in sepsis is impaired host immunity which results in failure to eradicate invading pathogens and increased susceptibility to secondary infections. Although many immunosuppressive mechanisms exist, increased expression of the inhibitory receptor progra...

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Bibliografiske detaljer
Main Authors: Chang, Katherine, Svabek, Catherine, Vazquez-Guillamet, Cristina, Sato, Bryan, Rasche, David, Wilson, Strother, Robbins, Paul, Ulbrandt, Nancy, Suzich, JoAnn, Green, Jonathan, Patera, Andriani C, Blair, Wade, Krishnan, Subramaniam, Hotchkiss, Richard
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056005/
https://ncbi.nlm.nih.gov/pubmed/24387680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc13176
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