Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15

Adoptive transfer of T lymphocytes expressing a CD19-specific chimeric antigen receptor (CAR.CD19) induces complete tumor regression in patients with lymphoid malignancies. Although in vivo persistence of CAR-T cells correlates with clinical responses, it remains unknown whether specific cell subset...

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Autori principali: Xu, Yang, Zhang, Ming, Ramos, Carlos A., Durett, April, Liu, Enli, Dakhova, Olga, Liu, Hao, Creighton, Chad J., Gee, Adrian P., Heslop, Helen E., Rooney, Cliona M., Savoldo, Barbara, Dotti, Gianpietro
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2014
Soggetti:
Gene Therapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055922/
https://ncbi.nlm.nih.gov/pubmed/24782509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-552174
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