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The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability
Translesion synthesis (TLS) enables DNA replication through damaged bases, increases cellular DNA damage tolerance, and maintains genomic stability. The sliding clamp PCNA and the adaptor polymerase Rev1 coordinate polymerase switching during TLS. The polymerases Pol η, ι, and κ insert nucleotides o...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4055408/ https://ncbi.nlm.nih.gov/pubmed/24922507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004419 |
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