Estrogen-Related Receptor Alpha Confers Methotrexate Resistance via Attenuation of Reactive Oxygen Species Production and P53 Mediated Apoptosis in Osteosarcoma Cells

Osteosarcoma (OS) is a malignant tumor mainly occurring in children and adolescents. Methotrexate (MTX), a chemotherapy agent, is widely used in treating OS. However, treatment failures are common due to acquired chemoresistance, for which the underlying molecular mechanisms are still unclear. In th...

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Main Authors: Chen, Peng, Wang, Haibin, Duan, Zhijian, Zou, June X., Chen, Hongwu, He, Wei, Wang, Junjian
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055217/
https://ncbi.nlm.nih.gov/pubmed/24967384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/616025
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