Activation of Estrogen Receptor Alpha by Decitabine Inhibits Osteosarcoma Growth and Metastasis

Osteosarcoma is a malignant tumor in the bone that originates from normal osteoblasts or osteoblast precursors. Normal osteoblasts express estrogen receptor alpha (ERα); however, osteosarcomas do not due to promoter DNA methylation. Here we show that treatment of 143B osteosarcoma cells with Decitab...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Osuna, Maria Angeles Lillo, Garcia-Lopez, Jesus, Ayachi, Ikbale El, Fatima, Iram, Khalid, Aysha B., Kumpati, Jerusha, Slayden, Alexandria V., Seagroves, Tiffany N., Miranda-Carboni, Gustavo A., Krum, Susan A.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420872/
https://ncbi.nlm.nih.gov/pubmed/30593524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1255
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