Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate

The radiosyntheses and in vivo evaluation of four carbon-11 labeled quinoline group-containing radioligands are reported here. Radiolabeling of [(11)C]1–4 was achieved by alkylation of their corrsponding desmethyl precursors with [(11)C]CH(3)I. Preliminary biodistribution evaluation in Sprague–Dawle...

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Autori principali: Fan, Jinda, Zhang, Xiang, Li, Junfeng, Jin, Hongjun, Padakanti, Prashanth K., Jones, Lynne A., Flores, Hubert P., Su, Yi, Perlmutter, Joel S., Tu, Zhude
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054929/
https://ncbi.nlm.nih.gov/pubmed/24721831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.03.028
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