Tumor Hypomethylation at 6p21.3 Associates with Longer Time to Recurrence of High-Grade Serous Epithelial Ovarian Cancer

In order to reveal biological mechanisms underlying clinical outcome of high-grade serous (HGS) epithelial ovarian carcinomas (EOC), we evaluated the association between tumor epigenetic changes and time to recurrence. We assessed methylation at approximately 450,000 genome-wide CpGs in tumors of 33...

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Autori principali: Wang, Chen, Cicek, Mine S., Charbonneau, Bridget, Kalli, Kimberly R., Armasu, Sebastian M., Larson, Melissa C., Konecny, Gottfried E., Winterhoff, Boris, Fan, Jian-Bing, Bibikova, Marina, Chien, Jeremy, Shridhar, Viji, Block, Matthew S., Hartmann, Lynn C., Visscher, Daniel W., Cunningham, Julie M., Knutson, Keith L., Fridley, Brooke L., Goode, Ellen L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054691/
https://ncbi.nlm.nih.gov/pubmed/24728075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3198
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