Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice

INTRODUCTION: The low-density lipoprotein receptor-related protein (LRP1) and its family members have been implicated in the pathogenesis of Alzheimer's disease. Multiple susceptibility factors converge to metabolic pathways that involve LRP1, including modulation of the processing of amyloid p...

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Main Authors: Xu, Guilian, Green, Cameron C, Fromholt, Susan E, Borchelt, David R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054673/
https://ncbi.nlm.nih.gov/pubmed/22537779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt110
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