STAT1β Is Not Dominant Negative and Is Capable of Contributing to Gamma Interferon-Dependent Innate Immunity

The transcription factor STAT1 is essential for interferon (IFN)-mediated immunity in humans and mice. STAT1 function is tightly regulated, and both loss- and gain-of-function mutations result in severe immune diseases. The two alternatively spliced isoforms, STAT1α and STAT1β, differ with regard to...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Semper, Christian, Leitner, Nicole R., Lassnig, Caroline, Parrini, Matthias, Mahlakõiv, Tanel, Rammerstorfer, Michael, Lorenz, Karin, Rigler, Doris, Müller, Simone, Kolbe, Thomas, Vogl, Claus, Rülicke, Thomas, Staeheli, Peter, Decker, Thomas, Müller, Mathias, Strobl, Birgit
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054301/
https://ncbi.nlm.nih.gov/pubmed/24710278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00295-14
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki