STAT1β Is Not Dominant Negative and Is Capable of Contributing to Gamma Interferon-Dependent Innate Immunity

The transcription factor STAT1 is essential for interferon (IFN)-mediated immunity in humans and mice. STAT1 function is tightly regulated, and both loss- and gain-of-function mutations result in severe immune diseases. The two alternatively spliced isoforms, STAT1α and STAT1β, differ with regard to...

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Autores principales: Semper, Christian, Leitner, Nicole R., Lassnig, Caroline, Parrini, Matthias, Mahlakõiv, Tanel, Rammerstorfer, Michael, Lorenz, Karin, Rigler, Doris, Müller, Simone, Kolbe, Thomas, Vogl, Claus, Rülicke, Thomas, Staeheli, Peter, Decker, Thomas, Müller, Mathias, Strobl, Birgit
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054301/
https://ncbi.nlm.nih.gov/pubmed/24710278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00295-14
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