Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain

Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial and sporadic Parkinson's disease (PD). LRRK2 is a complex protein that consists of multiple domains, including predicted C-terminal WD40 repeats. In this study, we analyzed functional and molecular features...

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Main Authors: Piccoli, Giovanni, Onofri, Franco, Cirnaru, Maria Daniela, Kaiser, Christoph J. O., Jagtap, Pravinkumar, Kastenmüller, Andreas, Pischedda, Francesca, Marte, Antonella, von Zweydorf, Felix, Vogt, Andreas, Giesert, Florian, Pan, Lifeng, Antonucci, Flavia, Kiel, Christina, Zhang, Mingjie, Weinkauf, Sevil, Sattler, Michael, Sala, Carlo, Matteoli, Michela, Ueffing, Marius, Gloeckner, Christian Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054300/
https://ncbi.nlm.nih.gov/pubmed/24687852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00914-13
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