TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

TopHat is a popular spliced aligner for RNA-sequence (RNA-seq) experiments. In this paper, we describe TopHat2, which incorporates many significant enhancements to TopHat. TopHat2 can align reads of various lengths produced by the latest sequencing technologies, while allowing for variable-length in...

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Bibliographic Details
Main Authors: Kim, Daehwan, Pertea, Geo, Trapnell, Cole, Pimentel, Harold, Kelley, Ryan, Salzberg, Steven L
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Method
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053844/
https://ncbi.nlm.nih.gov/pubmed/23618408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2013-14-4-r36
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