Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes

BACKGROUND: DNA methylation and the Polycomb repression system are epigenetic mechanisms that play important roles in maintaining transcriptional repression. Recent evidence suggests that DNA methylation can attenuate the binding of Polycomb protein components to chromatin and thus plays a role in d...

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Autori principali: Reddington, James P, Perricone, Sara M, Nestor, Colm E, Reichmann, Judith, Youngson, Neil A, Suzuki, Masako, Reinhardt, Diana, Dunican, Donncha S, Prendergast, James G, Mjoseng, Heidi, Ramsahoye, Bernard H, Whitelaw, Emma, Greally, John M, Adams, Ian R, Bickmore, Wendy A, Meehan, Richard R
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053768/
https://ncbi.nlm.nih.gov/pubmed/23531360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2013-14-3-r25
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