Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes

BACKGROUND: DNA methylation and the Polycomb repression system are epigenetic mechanisms that play important roles in maintaining transcriptional repression. Recent evidence suggests that DNA methylation can attenuate the binding of Polycomb protein components to chromatin and thus plays a role in d...

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Bibliografski detalji
Glavni autori: Reddington, James P, Perricone, Sara M, Nestor, Colm E, Reichmann, Judith, Youngson, Neil A, Suzuki, Masako, Reinhardt, Diana, Dunican, Donncha S, Prendergast, James G, Mjoseng, Heidi, Ramsahoye, Bernard H, Whitelaw, Emma, Greally, John M, Adams, Ian R, Bickmore, Wendy A, Meehan, Richard R
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053768/
https://ncbi.nlm.nih.gov/pubmed/23531360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2013-14-3-r25
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