SLAP deficiency decreases dsDNA autoantibody production

Src-like adaptor protein (SLAP) adapts c-Cbl, an E3 ubiquitin ligase, to activated components of the BCR signaling complex regulating BCR levels and signaling in developing B cells. Based on this function, we asked whether SLAP deficiency could decrease the threshold for tolerance and eliminate deve...

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Autori principali: Peterson, Lisa K., Pennington, Luke F., Shaw, Laura A., Brown, Meredith, Treacy, Eric C., Friend, Samantha F., Hatlevik, Øyvind, Rubtsova, Kira, Rubtsov, Anatoly V., Dragone, Leonard L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053206/
https://ncbi.nlm.nih.gov/pubmed/24440645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2013.12.007
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