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SLAP deficiency increases TCR avidity leading to altered repertoire and negative selection of cognate antigen-specific CD8(+) T cells
How T cell receptor (TCR) avidity influences CD8(+) T cell development and repertoire selection is not yet fully understood. To fill this gap, we utilized Src-like adaptor protein (SLAP)-deficient mice as a tool to increase TCR avidity on double positive (DP) thymocytes. We generated SLAP(−/−) mice...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3912270/ https://ncbi.nlm.nih.gov/pubmed/22956467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12026-012-8354-y |
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