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Optimization of rates of protein folding: the nucleation-condensation mechanism and its implications.

Small, single-module proteins that fold in a single cooperative step may be paradigms for understanding early events in protein-folding pathways generally. Recent experimental studies of the 64-residue chymotrypsin inhibitor 2 (CI2) support a nucleation mechanism for folding, as do some computer sti...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Autor principal: Fersht, A R
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40532/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479900/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.10869
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