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Optimization of rates of protein folding: the nucleation-condensation mechanism and its implications.

Small, single-module proteins that fold in a single cooperative step may be paradigms for understanding early events in protein-folding pathways generally. Recent experimental studies of the 64-residue chymotrypsin inhibitor 2 (CI2) support a nucleation mechanism for folding, as do some computer sti...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awdur: Fersht, A R
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 1995
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40532/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479900/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.10869
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