Utility of Redundant Combinatorial Libraries in Distinguishing High and Low Quality Screening Hits

[Image: see text] Large one-bead one-compound (OBOC) combinatorial libraries can be constructed relatively easily by solid-phase split and pool synthesis. The use of resins with hydrophilic surfaces, such as TentaGel, allows the beads to be used directly in screens for compounds that bind selectivel...

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Main Authors: Doran, Todd M., Gao, Yu, Mendes, Kimberly, Dean, Sonja, Simanski, Scott, Kodadek, Thomas
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053090/
https://ncbi.nlm.nih.gov/pubmed/24749624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/co500030f
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