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Utility of Redundant Combinatorial Libraries in Distinguishing High and Low Quality Screening Hits
[Image: see text] Large one-bead one-compound (OBOC) combinatorial libraries can be constructed relatively easily by solid-phase split and pool synthesis. The use of resins with hydrophilic surfaces, such as TentaGel, allows the beads to be used directly in screens for compounds that bind selectivel...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2014
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4053090/ https://ncbi.nlm.nih.gov/pubmed/24749624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/co500030f |
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