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Trends in Hit-to-Lead Optimization Following DNA-Encoded Library Screens
[Image: see text] DNA-encoded library (DEL) screens have emerged as a powerful hit-finding tool for a number of biological targets. In this Innovations article, we review published hit-to-lead optimization studies following DEL screens. Trends in molecular property changes from hit to lead are ident...
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| Gepubliceerd in: | ACS Med Chem Lett |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Chemical
Society
2021
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7957921/ https://ncbi.nlm.nih.gov/pubmed/33738060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00615 |
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