Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing

Tumor metastasis remains the major cause of cancer-related death, but its molecular basis is still not well understood. Here we uncovered a splicing-mediated pathway that is essential for breast cancer metastasis. We show that the RNA-binding protein heterogeneous nuclear ribonucleoprotein M (hnRNPM...

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Detalhes bibliográficos
Main Authors: Xu, Yilin, Gao, Xin D., Lee, Jae-Hyung, Huang, Huilin, Tan, Haiyan, Ahn, Jaegyoon, Reinke, Lauren M., Peter, Marcus E., Feng, Yue, Gius, David, Siziopikou, Kalliopi P., Peng, Junmin, Xiao, Xinshu, Cheng, Chonghui
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052765/
https://ncbi.nlm.nih.gov/pubmed/24840202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.241968.114
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