Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis

Drug resistance is a major issue in the treatment of glioblastoma. Almost all glioblastomas are intrinsically resistant to chemotherapeutic temozolomide (TMZ) or develop resistance during treatment. The interaction networks of microRNAs (miRNAs) and mRNAs likely regulate most biological processes an...

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Main Authors: Hiddingh, Lotte, Raktoe, Rajiv S., Jeuken, Judith, Hulleman, Esther, Noske, David P., Kaspers, Gertjan J. L., Vandertop, W. Peter, Wesseling, Pieter, Wurdinger, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052714/
https://ncbi.nlm.nih.gov/pubmed/24919120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05260
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