Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis

Drug resistance is a major issue in the treatment of glioblastoma. Almost all glioblastomas are intrinsically resistant to chemotherapeutic temozolomide (TMZ) or develop resistance during treatment. The interaction networks of microRNAs (miRNAs) and mRNAs likely regulate most biological processes an...

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Autori principali: Hiddingh, Lotte, Raktoe, Rajiv S., Jeuken, Judith, Hulleman, Esther, Noske, David P., Kaspers, Gertjan J. L., Vandertop, W. Peter, Wesseling, Pieter, Wurdinger, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052714/
https://ncbi.nlm.nih.gov/pubmed/24919120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05260
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