EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastoma

Glioblastoma is the most common malignant primary brain tumor. Temozolomide (TMZ) is the standard chemotherapeutic agent for this disease. However, intrinsic and acquired TMZ-resistance represents a major obstacle for this therapy. In order to identify factors involved in TMZ-resistance, we engineer...

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Main Authors: Hiddingh, Lotte, Tannous, Bakhos A., Teng, Jian, Tops, Bas, Jeuken, Judith, Hulleman, Esther, Boots-Sprenger, Sandra H., Vandertop, W. Peter, Noske, David P., Kaspers, Gertjan J.L., Wesseling, Pieter, Wurdinger, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2013
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964213/
https://ncbi.nlm.nih.gov/pubmed/24495907
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