Autocrine A2 in the T-System of Ventricular Myocytes Creates Transmural Gradients in Ion Transport: A Mechanism to Match Contraction with Load?

Transmural heterogeneities in Na/K pump current (I(P)), transient outward K(+)-current (I(to)), and Ca(2+)-current (I(CaL)) play an important role in regulating electrical and contractile activities in the ventricular myocardium. Prior studies indicated angiotensin II (A2) may determine the transmur...

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Detalhes bibliográficos
Main Authors: Gao, Junyuan, Sun, Xiurong, Potapova, Irina A., Cohen, Ira S., Mathias, Richard T., Kim, Jeremy H.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2014
Assuntos:
Channels and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052267/
https://ncbi.nlm.nih.gov/pubmed/24896115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.04.042
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