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Autocrine A2 in the T-System of Ventricular Myocytes Creates Transmural Gradients in Ion Transport: A Mechanism to Match Contraction with Load?

Transmural heterogeneities in Na/K pump current (I(P)), transient outward K(+)-current (I(to)), and Ca(2+)-current (I(CaL)) play an important role in regulating electrical and contractile activities in the ventricular myocardium. Prior studies indicated angiotensin II (A2) may determine the transmur...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gao, Junyuan, Sun, Xiurong, Potapova, Irina A., Cohen, Ira S., Mathias, Richard T., Kim, Jeremy H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Biophysical Society 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052267/
https://ncbi.nlm.nih.gov/pubmed/24896115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.04.042
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