Reporter Assay for Endo/Lysosomal Escape of Toxin-Based Therapeutics

Protein-based therapeutics with cytosolic targets are capable of exhibiting their therapeutic effect once they have escaped from the endosomes or lysosomes. In this study, the reporters—horseradish peroxidase (HRP), Alexa Fluor 488 ((Alexa)) and ricin A-chain (RTA)—were investigated for their capaci...

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Main Authors: Gilabert-Oriol, Roger, Thakur, Mayank, von Mallinckrodt, Benedicta, Bhargava, Cheenu, Wiesner, Burkhard, Eichhorst, Jenny, Melzig, Matthias F., Fuchs, Hendrik, Weng, Alexander
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052257/
https://ncbi.nlm.nih.gov/pubmed/24859158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins6051644
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