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Effects of the Protonation State of the EEEE Motif of a Bacterial Na(+)-channel on Conduction and Pore Structure

A distinctive feature of prokaryotic Na(+)-channels is the presence of four glutamate residues in their selectivity filter. In this study, how the structure of the selectivity filter, and the free-energy profile of permeating Na(+) ions are altered by the protonation state of Glu177 are analyzed. It...

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Detalhes bibliográficos
Main Authors: Furini, Simone, Barbini, Paolo, Domene, Carmen
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052246/
https://ncbi.nlm.nih.gov/pubmed/24853746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.04.005
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