The Genetic and Biochemical Basis of FANCD2 Monoubiquitination

Fanconi anaemia (FA) is a cancer predisposition syndrome characterized by cellular sensitivity to DNA interstrand crosslinkers. The molecular defect in FA is an impaired DNA repair pathway. The critical event in activating this pathway is monoubiquitination of FANCD2. In vivo, a multisubunit FA core...

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Main Authors: Rajendra, Eeson, Oestergaard, Vibe H., Langevin, Frédéric, Wang, Meng, Dornan, Gillian L., Patel, Ketan J., Passmore, Lori A.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051986/
https://ncbi.nlm.nih.gov/pubmed/24905007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.05.001
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