The Genetic and Biochemical Basis of FANCD2 Monoubiquitination

Fanconi anaemia (FA) is a cancer predisposition syndrome characterized by cellular sensitivity to DNA interstrand crosslinkers. The molecular defect in FA is an impaired DNA repair pathway. The critical event in activating this pathway is monoubiquitination of FANCD2. In vivo, a multisubunit FA core...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Rajendra, Eeson, Oestergaard, Vibe H., Langevin, Frédéric, Wang, Meng, Dornan, Gillian L., Patel, Ketan J., Passmore, Lori A.
Format: Artigo
Langue:Inglês
Publié: Cell Press 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051986/
https://ncbi.nlm.nih.gov/pubmed/24905007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.05.001
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires