Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities

The ALKBH family of Fe(II) and 2-oxoglutarate dependent oxygenases comprises enzymes that display sequence homology to AlkB from E. coli, a DNA repair enzyme that uses an oxidative mechanism to dealkylate methyl and etheno adducts on the nucleobases. Humans have nine different ALKBH proteins, ALKBH1...

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Autors principals: Zdżalik, Daria, Vågbø, Cathrine B., Kirpekar, Finn, Davydova, Erna, Puścian, Alicja, Maciejewska, Agnieszka M., Krokan, Hans E., Klungland, Arne, Tudek, Barbara, van den Born, Erwin, Falnes, Pål Ø.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051686/
https://ncbi.nlm.nih.gov/pubmed/24914785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098729
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