Hypoxia-Inducible Factor-2α Is an Essential Catabolic Regulator of Inflammatory Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a systemic autoimmune disorder that manifests as chronic inflammation and joint tissue destruction. However, the etiology and pathogenesis of RA have not been fully elucidated. Here, we explored the role of the hypoxia-inducible factors (HIFs), HIF-1α (encoded by HIF1A)...

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Main Authors: Ryu, Je-Hwang, Chae, Chang-Suk, Kwak, Ji-Sun, Oh, Hwanhee, Shin, Youngnim, Huh, Yun Hyun, Lee, Choong-Gu, Park, Yong-Wook, Chun, Churl-Hong, Kim, Young-Myeong, Im, Sin-Hyeog, Chun, Jang-Soo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051611/
https://ncbi.nlm.nih.gov/pubmed/24914685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001881
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