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Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6′)-Ie-APH(2′′)-Ia

The bifunctional acetyltransferase(6′)-Ie-phosphotransfer­ase(2′′)-Ia [AAC(6′)-Ie-APH(2′′)-Ia] is the most important aminoglycoside-resistance enzyme in Gram-positive bacteria, conferring resistance to almost all known aminoglycoside antibiotics in clinical use. Owing to its importance, this enzyme...

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Main Authors: Smith, Clyde A., Toth, Marta, Bhattacharya, Monolekha, Frase, Hilary, Vakulenko, Sergei B.
Formato: Artigo
Idioma:Inglês
Publicado: International Union of Crystallography 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051501/
https://ncbi.nlm.nih.gov/pubmed/24914967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004714005331
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