Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress

TSP-1 is a physiologic activator of TGF-β, a critical induction factor for Th17-mediated immunity. The purpose of this study was to investigate the role of TSP-1 in the induction of the Th17 ocular surface response to DS. TSP-1KO and WT mice were subjected to DS5 and DS10), and parameters of ocular...

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Главные авторы: Gandhi, Niral B., Su, Zhitao, Zhang, Xiaobo, Volpe, Eugene A., Pelegrino, Flavia S. A., Rahman, Salman A., Li, De-Quan, Pflugfelder, Stephen C., de Paiva, Cintia S.
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Leukocyte Biology 2013
Предметы:
Inflammation, Extracellular Mediators, & Effector Molecules
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051277/
https://ncbi.nlm.nih.gov/pubmed/23983225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1012524
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