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Desiccating Stress Induces CD4(+) T-Cell–Mediated Sjögren's Syndrome–Like Corneal Epithelial Apoptosis via Activation of the Extrinsic Apoptotic Pathway by Interferon-γ
We investigated the role of CD4(+) T-cell–produced interferon (IFN)-γ on corneal epithelial apoptosis in a murine desiccating stress (DS) model that resembles Sjögren's syndrome. The DS model was generated in C57BL/6 (B6) and B6 IFN-γ–knockout (B6γKO) mice. Adoptive transfer of CD4(+) T cells f...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Investigative Pathology
2011
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3181354/ https://ncbi.nlm.nih.gov/pubmed/21843497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.06.030 |
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