Desiccating Stress Induces CD4(+) T-Cell–Mediated Sjögren's Syndrome–Like Corneal Epithelial Apoptosis via Activation of the Extrinsic Apoptotic Pathway by Interferon-γ

We investigated the role of CD4(+) T-cell–produced interferon (IFN)-γ on corneal epithelial apoptosis in a murine desiccating stress (DS) model that resembles Sjögren's syndrome. The DS model was generated in C57BL/6 (B6) and B6 IFN-γ–knockout (B6γKO) mice. Adoptive transfer of CD4(+) T cells f...

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Main Authors: Zhang, Xiaobo, Chen, Wei, De Paiva, Cintia S., Volpe, Eugene A., Gandhi, Niral B., Farley, William J., Li, De-Quan, Niederkorn, Jerry Y., Stern, Michael E., Pflugfelder, Stephen C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2011
Teme:
Regular Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181354/
https://ncbi.nlm.nih.gov/pubmed/21843497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.06.030
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