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Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia
Mutations in the genetic sequence of the DNA de novo methyltransferase DNMT3A (DNA methyltransferase 3A) are found in many patients with acute myeloid leukemia (AML). They lead to dysfunction of DNMT3A protein and represent a marker for poor prognosis. Effects of genetic mutations can be mimicked by...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4051212/ https://ncbi.nlm.nih.gov/pubmed/24280869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.362 |
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