Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia

Mutations in the genetic sequence of the DNA de novo methyltransferase DNMT3A (DNA methyltransferase 3A) are found in many patients with acute myeloid leukemia (AML). They lead to dysfunction of DNMT3A protein and represent a marker for poor prognosis. Effects of genetic mutations can be mimicked by...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Jost, E, Lin, Q, Weidner, C I, Wilop, S, Hoffmann, M, Walenda, T, Schemionek, M, Herrmann, O, Zenke, M, Brümmendorf, T H, Koschmieder, S, Wagner, W
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2014
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051212/
https://ncbi.nlm.nih.gov/pubmed/24280869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.362
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