Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

Type 2 diabetes mellitus (T2DM) progresses from compensated insulin resistance to beta ceil failure resulting in uncompensated hyperglycemia, a process replicated in the Zucker diabetic fatty (ZDF) rat. The Nlrp3 inflammasome has been implicated in obesity-induced insulin resistance and beta cell fa...

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Main Authors: Jourdan, Tony, Godlewski, Grzegorz, Cinar, Resat, Bertola, Adeline, Szanda, Gergö, Liu, Jie, Tarn, Joseph, Han, Tiffany, Mukhopadhyay, Bani, Skarulis, Monica C, Ju, Cynthia, Aouadis, Myriam, Czech, Michael P, Kunos, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050982/
https://ncbi.nlm.nih.gov/pubmed/23955712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3265
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