Combinatorial actions of Tgfβ and Activin ligands promote oligodendrocyte development and CNS myelination

In the embryonic CNS, development of myelin-forming oligodendrocytes is limited by bone morphogenetic proteins, which constitute one arm of the transforming growth factor-β (Tgfβ) family and signal canonically via Smads 1/5/8. Tgfβ ligands and Activins comprise the other arm and signal via Smads 2/3...

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Autors principals: Dutta, Dipankar J., Zameer, Andleeb, Mariani, John N., Zhang, Jingya, Asp, Linnea, Huynh, Jimmy, Mahase, Sean, Laitman, Benjamin M., Argaw, Azeb Tadesse, Mitiku, Nesanet, Urbanski, Mateusz, Melendez-Vasquez, Carmen V., Casaccia, Patrizia, Hayot, Fernand, Bottinger, Erwin P., Brown, Chester W., John, Gareth R.
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists 2014
Matèries:
Stem Cells and Regeneration
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050697/
https://ncbi.nlm.nih.gov/pubmed/24917498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.106492
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