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Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1

Hutchinson–Gilford progeria syndrome (HGPS) is a severe human premature aging disorder caused by a lamin A mutant named progerin. Death occurs at a mean age of 13 y from cardiovascular problems. Previous studies revealed loss of vascular smooth muscle cells (SMCs) in the media of large arteries in a...

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Detalhes bibliográficos
Main Authors: Zhang, Haoyue, Xiong, Zheng-Mei, Cao, Kan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050581/
https://ncbi.nlm.nih.gov/pubmed/24843141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320843111
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