Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells

Insulin resistance, hyperinsulinemia, and hyperproinsulinemia occur early in the pathogenesis of type 2 diabetes (T2D). Elevated levels of proinsulin and proinsulin intermediates are markers of β-cell dysfunction and are strongly associated with development of T2D in humans. However, the mechanism(s...

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Main Authors: Liew, Chong Wee, Assmann, Anke, Templin, Andrew T., Raum, Jeffrey C., Lipson, Kathryn L., Rajan, Sindhu, Qiang, Guifen, Hu, Jiang, Kawamori, Dan, Lindberg, Iris, Philipson, Louis H., Sonenberg, Nahum, Goldfine, Allison B., Stoffers, Doris A., Mirmira, Raghavendra G., Urano, Fumihiko, Kulkarni, Rohit N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2014
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050564/
https://ncbi.nlm.nih.gov/pubmed/24843127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323066111
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