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Generation of a genomic reporter assay system for analysis of γ- and β-globin gene regulation

A greater understanding of the regulatory mechanisms that govern γ-globin expression in humans, especially the switching from γ- to β-globin, which occurs after birth, would help to identify new therapeutic targets for patients with β-hemoglobinopathy. To further elucidate the mechanisms involved in...

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Main Authors: Chan, Kasey S. K., Xu, Jian, Wardan, Hady, McColl, Bradley, Orkin, Stuart, Vadolas, Jim
Formato: Artigo
Idioma:Inglês
Publicado: Federation of American Societies for Experimental Biology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050337/
https://ncbi.nlm.nih.gov/pubmed/22267339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-199356
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