Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb

Although the role of noxious α-synuclein (α-SYN) in the degeneration of midbrain dopaminergic neurons and associated motor deficits of Parkinson’s disease is recognized, its impact on non-motor brain circuits and related symptoms remains elusive. Through combining in vivo two-photon imaging with tim...

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Main Authors: Neuner, Johanna, Ovsepian, Saak V., Dorostkar, Mario, Filser, Severin, Gupta, Aayush, Michalakis, Stylianos, Biel, Martin, Herms, Jochen
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050256/
https://ncbi.nlm.nih.gov/pubmed/24867427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4915
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