TopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeres

Telomeres are repetitive nucleoprotein structures at the ends of chromosomes. Like most genomic regions consisting of repetitive DNA, telomeres are fragile sites prone to replication fork stalling and generation of chromosomal instability. In particular, abrogation of the TRF1 telomere binding prote...

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Bibliographic Details
Main Authors: d’Alcontres, Martina Stagno, Palacios, Jose Alejandro, Mejias, Diego, Blasco, Maria A
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050144/
https://ncbi.nlm.nih.gov/pubmed/24626180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28419
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