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Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions
The shelterin protein TRF2 is essential for chromosome-end protection. Depletion of TRF2 causes chromosome end-to-end fusions, initiating genomic instability that can be cancer promoting. Paradoxically, significant increased levels of TRF2 are observed in a subset of human cancers. Experimental over...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4686832/ https://ncbi.nlm.nih.gov/pubmed/26640040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10132 |
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