Cell cycle synchronization of leukemia inhibitory factor (LIF)-dependent porcine-induced pluripotent stem cells and the generation of cloned embryos

Nuclear transfer (NT) from porcine iPSC to create cloned piglets is unusually inefficient. Here we examined whether such failure might be related to the cell cycle stage of donor nuclei. Porcine iPSC, derived here from the inner cell mass of blastocysts, have a prolonged S phase and are highly sensi...

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Bibliographische Detailangaben
Hauptverfasser: Yuan, Ye, Lee, Kiho, Park, Kwang-Wook, Spate, Lee D, Prather, Randall S, Wells, Kevin D, Roberts, R Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2014
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049963/
https://ncbi.nlm.nih.gov/pubmed/24621508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28176
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