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Fingolimod Attenuates Splenocyte-Induced Demyelination in Cerebellar Slice Cultures
The family of sphingosine-1-phosphate receptors (S1PRs) is G-protein-coupled, comprised of subtypes S1PR1-S1PR5 and activated by the endogenous ligand S1P. The phosphorylated version of Fingolimod (pFTY720), an oral therapy for multiple sclerosis (MS), induces S1PR1 internalisation in T cells, subse...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4049809/ https://ncbi.nlm.nih.gov/pubmed/24911000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099444 |
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