dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: A dual-institutional follow-up with the RTOG 9704 trial

Deoxycytidine kinase (dCK) and human antigen R (HuR) have been associated with response to gemcitabine in small studies. The present study investigates the prognostic and predictive value of dCK and HuR expression levels for sensitivity to gemcitabine and 5-fluorouracil (5-FU) in a large phase III a...

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Main Authors: McAllister, Florencia, Pineda, Danielle M, Jimbo, Masaya, Lal, Shruti, Burkhart, Richard A, Moughan, Jennifer, Winter, Kathryn A, Abdelmohsen, Kotb, Gorospe, Myriam, de Jesus Acosta, Ana, Lankapalli, Rachana H, Winter, Jordan M, Yeo, Charles J, Witkiewicz, Agnieska K, Iacobuzio-Donahue, Christine A, Laheru, Daniel, Brody, Jonathan R
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2014
Subjects:
Clinical Study
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049785/
https://ncbi.nlm.nih.gov/pubmed/24618665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.28413
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